Arcángel and De La Ghetto duo began when they met in a studio in San Juan, Puerto Rico. After many hits and shows, they decided to break up the duo and pursue their talents as solo artists. They still make songs together on occasion but are no longer a duo. After launching his career and gaining notability, he collaborated with J Balvin, Reykon, Yelsid, Zion, Daddy Yankee, Héctor "El Father", Jowell & Randy, Don Omar, Tito "El Bambino", Ivy Queen, Yaga & Mackie, Tego Calderón, Ñejo & Dalmata, Alexis & Fido, and Voltio, among others. De La Ghetto became known in 2005 with the single "Ven Pégate", a duet with Arcángel on the reggaeton compilation Sangre Nueva, which opened doors allowing him to participate in later reggaeton compilation albums.
It was announced that they will reunite again to release an album together in 2013 under title Juntos Por Necesidad Del Genero.