Harris began her career as a rapper by releasing material through the internet in late 2012. In 2015, two of her songs, "Deepthroat" and "Vagina", went viral on video sharing websites such as YouTube and WorldStarHipHop. The songs were later included on her debut mixtape Cum Cake, which was released in February 2016 and placed at #23 in Rolling Stone's "Best Rap Albums of 2016" list and received attention from Pitchfork. Her hyper-sexualized and often comical lyrical content has gained her songs notoriety across the internet, and she has since developed a strong online fanbase whom she nicknamed "slurpers".
Her second mixtape, S.T.D (Shelters to Deltas), was released in 2016 and was included in Rolling Stone's June 2016 list of the "Best Rap Albums of 2016 So Far". She has also received attention from music publications Complex and The Fader.
Following the release of her mixtapes, Harris debuted her album Audacious in 2016. Her second studio album Queen Elizabitch was released in 2017. In 2018, it was followed by her third studio album Ephorize.