In 2013 on the DizastaMusic YouTube channel, Miller created the video Do the Harlem Shake (Original), which originated from a clip of the video "Filthy Compilation #6 – Smell My Fingers", the video has been viewed 59 million times (as of January 2018[update]). The original clip led to the creation of the Harlem Shake meme, which was directly responsible for the debut of Baauer's "Harlem Shake" song atop the Billboard Hot 100. In addition to the DizastaMusic channel (inactive since 2015), he has operated two other channels: TooDamnFilthy (a secondary channel) and TVFilthyFrank (main channel).
His absurdist YouTube channel, now defunct, consisted of music, rants, ukulele performances and a bizarre show, with all of the main characters played by Miller including the titular character of Filthy Frank. As of late 2017, Miller has stepped away from the channel and is focusing on his music career.